Celecoxib Capsules

Each hard gelatin capsule contains:

• Celecoxib – 200 mg

Therapeutic Class:
Selective COX-2 Inhibitor – Used for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain.
 

Celecoxib Capsule is a selective cyclooxygenase-2 (COX-2) inhibitor, which is a non-steroidal anti-inflammatory drug (NSAID). It is famous for having a lower risk of causing gastrointestinal bleeding than other NSAIDs.

How Celecoxib Works ?

Celecoxib Capsule is a selective, non-competitive inhibitor of the COX-2 enzyme. Unlike most NSAIDs that inhibit both COX-1 and COX-2 enzymes, celecoxib is selective in inhibiting only the COX-2 enzyme. This selectivity is the most important feature of its mechanism of action.

Inhibition of COX-2 by celecoxib suppresses the formation of prostaglandins and other metabolites in the pain and inflammation pathway, for example, prostacyclin (PGI2) and thromboxane (TXA2).

How to Use Celecoxib Tablet?

• Celecoxib is a drug that is taken orally in capsule and liquid form:

Dosage

• Celecoxib capsules are prepared in strengths of 50mg, 100mg, 200mg, and 400mg. 
• The solution medication is prepared with a strength of 25mg/mL (120mg/4.8mL).

Administration Guidelines

• Swallow celecoxib capsules whole with or without food as directed by your physician.
• Store any leftover capsule-applesauce mixture in the refrigerator and drink it within 6 hours.
• Take the medication directly from the bottle for the 120mg dosage.
• Use an oral dosing syringe to draw and measure 2.4mL from the bottle and administer it for the 60mg dosage.
• Do not use a household teaspoon to measure the oral solution because it could result in an improper dose.

Side Effects of Celecoxib Capsule

As with other drugs, celecoxib caosule can also have side effects, including:

Common Side Effects: The most common side effects are:

• Gastrointestinal symptoms: gas, bloating, constipation, diarrhoea, nausea, vomiting, abdominal pain
• Upper respiratory tract infection symptoms: sore throat, cold
• Dizziness
• Disturbance in taste sensation (dysgeusia)
• Serious Side Effects: Although less common, celecoxib can also have serious side effects:
• Sudden gain in weight
• Shortness of breath or shortness of breath
• Swelling of the belly, feet, ankles, or lower legs
• Chest pain, sudden weakness or numbness, slurred speech (Symptoms of heart attack or stroke)
• Gastrointestinal bleeding
• Diarrhea
• Nausea and loss of appetite
• Extreme tiredness
• Unexplained bleeding or bruising
• Blood in vomit or stool
• Itching
• Right upper stomach pain
• Yellowish discolouration of skin or eyes
• Allergic reaction, for example, symptoms of flu, rash, hives, eye, face, tongue, lips, throat, or hand swelling, difficulty in breathing
• Hoarseness
• Painful or hard urination
• Increased frequency of urination, particularly at night
• Cloudy, discoloured, or bloody urine

Precautions

It is essential to tell your doctor about any current systemic conditions, drugs, or supplements you take before taking celecoxib capsule.

Pregnancy and Breastfeeding: Celecoxib capsule is administered during late pregnancy can cause injury to the foetus. Celecoxib can pass into the breast milk. So, talk to your doctor before breastfeeding after consuming this drug.

Fertility: Celecoxib capsule can lead to a delay in ovulation for women and impair their fertility.

Cardiovascular Risks: Long-term celecoxib capsule intake increases the risk of heart attack or stroke, especially in individuals with established heart disease.

Gastrointestinal Bleeding: Celecoxib can lead to stomach or intestinal bleeding without any warning symptoms.

Liver and Kidney Issues: Celecoxib capsules can cause liver and kidney issues. If you have the symptoms of abdominal pain, dark urine, reduced urination, swelling, feeling unusually tired, loss of appetite, nausea, vomiting, or yellowing of the skin and eyes, seek immediate medical advice.

Allergic Reactions: Celecoxib capsule may cause severe allergic reactions, such as anaphylaxis, which is a medical emergency. Visit emergency care if you find you have a rash, itching, swelling, or trouble breathing or swallowing.

Surgical Procedures: Tell your physician if you are undergoing any type of surgical procedure or medical tests, since it might be important to temporarily discontinue celecoxib or change to a different drug.