Progesterone Gel

Composition (Each gram contains):
Progesterone: 8.0% w/w

Dosage Form: Gel

Therapeutic Class: Hormone Therapy

Progesterone Gel 8% contains progesterone, a hormone that is vital in regulating ovulation and maintaining pregnancy. Often used in conditions where progesterone is low and in assisted reproductive technology (ART) procedures.

Your doctor should be informed if you have a history of breast cancer, bleeding from your vagina for unknown reasons, liver disease, or any other medical issues. You should also let them know about all of your medications. During therapy, stay away from other vaginal items and anticipate having your womb monitored by testing.

Mechanism of Action:

Progesterone helps sustain pregnancy by preparing the uterus for the implantation of a fertilized egg. The vaginal gel can be applied directly to the uterus, ensuring that the progesterone is absorbed and acts in that area.

Progesterone Gel Uses:

• Progesterone Deficiency

Dosage and Administration:

• For 1 day, typically after ovulation or egg retrieval, 90 mg of Progesterone Gel 8% (1 applicatorful) is inserted into the vagina.
• If pregnancy occurs, treatment can be continued as prescribed and is sometimes continued until the first 10-12 weeks of pregnancy.

Side Effects of Progesterone Gel 8%:

• Vaginal itching
• Burning
• Complain of discomfort at application site.
• Breast tenderness
• Bloating
• Mood swings
• Fatigue
• Rash
• Itching
• Swelling

Storage:

• Keep the applicators in their original package to protect them from moisture and light and maintain a controlled room temperature of 20°C - 25°C.

How Do You Use This Medication?

• Progesterone Gel 8% is used in ART/fertility therapies, either once a day or twice a day, for up to 10/12 weeks. 
• However, in the treatment of amenorrhea, it is given one every other day for six doses, and can be given another six if needed. 
• Always follow the doctor's instructions and never adjust the dosage without consulting with the doctor. 
• Ask your pharmacist or doctor if you have any questions about its use.

Frequently Asked Questions (FAQs):

What is Progesterone Gel 8%?
Progesterone Gel 8% contains the natural female hormone progesterone. May be used during assisted reproduction therapy (ART) to potentially help maintain the uterine lining or for secondary amenorrhea.

What is the action of Progesterone Gel 8%?
It is thought to help the body's progesterone levels, which may aid in preparing and maintaining the lining of the uterus to receive the embryo.

What could be its specific uses?
It is widely used in the luteal phase in IVF treatments and in women with irregular periods or those that do not occur even when the progesterone is low.

What's the way to take Progesterone Gel 8%?
It's inserted vaginally with the included pre-filled applicators, typically once or twice a day as directed by a doctor.

Does the vagina dribble after use?
Discharge could be seen as small white globules, which is normal as the gel expels from the vagina over a couple of days.

What are the possible side effects?
Breast tenderness, bloating, small cramps in the abdomen, tiredness, or fluctuations in mood may occur in some users.

What should I do if I fall asleep after I've used the product?
Generally, lying down is not required after placing the gel in place, since it will adhere to the walls of the vagina.

Can it be used with other vaginal products?
Other vaginal therapies have been recommended to avoid use at the same time, as it can affect how the gel is absorbed.

What is the typical duration of treatment?
If pregnancy occurs during ART, treatment may potentially be continued for up to 10–12 weeks of pregnancy, under medical advice.

What is its storage method?
Proper storage is at room temperature, typically less than 25°C, and avoid extreme temperatures.